AZD-9291 Anticancer Drug CAS 1421373-65-0 AZD9291 lung cancer Treatment Drug

AZD-9291 Anticancer Drug CAS 1421373-65-0 AZD9291 lung cancer Treatment Drug

AZD-9291 Anticancer Drug CAS 1421373-65-0 AZD9291 lung cancer Treatment Drug

AZD-9291
Other Names: N(2{[2(diMethylaMino)ethyl](Methyl)aMino}4Methoxy5{[4(1Methyl1Hindol3yl)pyriMidin2yl]aMino}phenyl)prop2enaMide;N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide;AZD9291,AZD-9291
CAS:    1421373-65-0
MF:    C28H33N7O2
MW:    499.61 .

AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). AZD 9291 has been shown to inhibit tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg and has been tested clinically in patients with advanced EGFR mutant non-small-cell lung cancer.

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